教員業績データベース - 藤原範子

（最終更新日：2022-06-28 17:27:10）

  フジワラノリコ   Fujiwara Noriko
  藤原範子
   所属   （専門部門）基礎医学系講座生化学

職種教育教授

■ 学術論文

1.	原著	Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits 1996/01
2.	原著	Quinazoline derivatives suppress nitric oxide production by macrophages through inhibition of NOS II gene expression 1996/10
3.	原著	Roles of purine nucleotides and adenosine in enhancing NOS II gene expression in interleukin-1β-stimulated rat vascular smooth muscle cells 1997/01
4.	原著	Functional expression of rat thioredoxin reductase: Selenocysteine insertion sequence element is essential for the active enzyme 1999/06
5.	原著	A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivative 2000/04
6.	その他	医学研究 NO合成酵素活性測定法(放射性同位体を用いる方法) 2000/04
7.	その他	【SIRS メディエータのマーチ】SIRSの病態 SIRSとNO・活性酸素 2000/09
8.	原著	Roles of N-terminal active cysteines and C-terminal cysteine-selenocysteine in the catalytic mechanism of mammalian thioredoxin reductase 2001/01
9.	原著	Estrogen Induces the Akt-dependent Activation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells 2001/02
10.	その他	スーパーオキシドジスムターゼ 2002/01
11.	原著	Induction of thioredoxin reductase gene expression by peroxynitrite in human umbilical vein endothelial cells. 2002/03
12.	その他	【アンティ・オキシダントの基礎と臨床】抗酸化酵素(スーパーオキシドジスムターゼ,カタラーゼ,グルタチオン関連酵素,チオレドキシン関連酵素) 2002/08
13.	原著	Novel substrates for nitric oxide synthases. 2002/09
14.	原著	Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses. 2003/04
15.	原著	Different immunoreactivity against monoclonal antibodies between wild-type and mutant copper/zinc superoxide dismutase linked to amyotrophic lateral sclerosis. 2005/02
16.	原著	Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells. 2005/02
17.	原著	Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal change. 2005/02
18.	原著	Clostridium botulinum type A progenitor toxin binds to Intestine-407 cells via N-acetyllactosamine moiety. 2005/06
19.	原著	Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion. 2005/11
20.	原著	Reactive oxygen species modify oligosaccharides of glycoproteins in vivo: a study of a spontaneous acute hepatitis model rat (LEC rat). 2006/03
21.	原著	Effects of copper metabolism on neurological functions in Wistar and Wilson's disease model rats. 2006/10
22.	研究報告	Neurochemical characterization of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson's disease 2008/01
23.	その他	ヒトCu,Zn-SOD(SOD1)のシステイン残基の酸化的修飾とその特異抗体の開発 2008/07
24.	その他	ALSにおける酸化ストレスおよび酸化型SOD1の関与 2009/01
25.	原著	Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice. 2009/09
26.	その他	酸化ストレスと健康 2009/09
27.	その他	Antioxidants: Benefits and risks for long-term health 2010/10
28.	原著	Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice. 2010/10
29.	原著	The role of O-linked GlcNAc modification on the glucose response of ChREBP. 2010/11
30.	総説	Benefits and risks of antioxidants for health 2010/12
31.	原著	Hydrogen peroxide enhances LPS-induced nitric oxide production via the expression of interferon beta in BV-2 microglial cells. 2011/04
32.	その他	Oxidation of Cys111 residue in loop VI of human copper/zinc superoxide dismutase 2011/07
33.	その他	The role of O-linked GlcNAc modification on the glucose response of ChREBP 2011/07
34.	その他	Cu、Zn-スーパーオキシドジスムターゼに関する研究 2011/12
35.	原著	Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43. 2012/01
36.	原著	Oxidative modification of cysteine 111 promotes disulfide bond-independent aggregation of SOD1. 2012/04
37.	原著	Alterations in renal iron metabolism caused by a copper/zinc-superoxide dismutase deficiency. 2012/06
38.	原著	Structural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzyme. 2012/12
39.	原著	A solution 17O-NMR approach for observing an oxidized cysteine residue in Cu,Zn-superoxide dismutase 2013/02
40.	原著	Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43). 2013/05
41.	原著	A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS. 2015/06
42.	原著	The absence of the SOD1 gene causes abnormal monoaminergic neurotransmission and motivational impairment-like behavior in mice. 2016/01
43.	原著	Cu,Zn-SOD deficiency induces accumulation of hepatic collagen. 2016/04
44.	その他	Solution oxygen-17 NMR application for observing a peroxidized cysteine residue in oxidized human SOD1. 2016/04
45.	原著	The absence of the SOD1 gene causes abnormal monoaminergic neurotransmission and motivational impairment-like behavior in mice 2016/10
46.	その他	転写因子ChREBPを標的とした生活習慣病の予防法および治療薬の開発 2017/02
47.	原著	Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state. 2018
48.	その他	筋萎縮性側索硬化症に関与するCu、Zn-スーパーオキシドディスムターゼの研究 2018/03
49.	原著	Basic skills examination in a biochemical practical training program for undergraduate students. 2019/05
50.	原著	Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis 2019/11
51.	原著	Introduction of team-based learning improves understanding of glucose metabolism in biochemistry among undergraduate students. 2020/12
52.	原著	Activation of the mitogen-activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells. 2021/07
53.	原著	A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue 2021/10
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■ 著書

1.	その他	Nitric Oxide Donors: For Pharmaceutical and Biological Applications, Nitric Oxide Donors: For Pharmaceutical and Biological Applications 2005/05
2.	その他	Systems biology of free radicals and anti-oxidants, Systems biology of free radicals and anti-oxidants 2014/01
3.	分担執筆	はじめに:酸化ストレスとは,グルタチオン, タンパク質の酸化的修飾, メイラード反応と活性酸素, 老化の活性酸素説, 老化とミトコンドリア, 抗酸化酵素と寿命, カロリーと寿命「活性酸素の本当の姿」 2014/02
4.	分担執筆	第2章活性酸素の生成・消去は日常茶飯事「活性酸素の本当の姿」 2014/02
5.	分担執筆	Anti-oxidant use in humans: successes and failures., Systems Biology of Free Radicals and Anti-Oxidants. 2014/06
6.	その他	生化学 (カラーイラストで学ぶ集中講義), 生化学 (カラーイラストで学ぶ集中講義) 2017/03
7.	分担執筆	「改訂2版カラーイラストで学ぶ集中講義生化学」 2017/04
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