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Journal
Presentation
    （Last updated : 2022-06-03 09:23:14）
  Tomita Toshihiko
   Department   Specialty Division  , Clinical Medicine Subject
   Specialty Division  , Clinical Medicine Seminars
   Position  
■ Journal
1. Introduction　 Carcinogenesis of Barrett's esophagus: a review of the clinical literature 2013
2. Original article　 Use of scintigraphy to evaluate gastric accommodation and emptying: comparison with barostat. 2013/01
3. Original article　 REG Iα is a biomarker for predicting response to chemotherapy with S-1 plus cisplatin in patients with unresectable stage IV gastric cancer. 2013/02
4. Original article　 Effect of age and correlation between esophageal visceral chemosensitivity and mechanosensitivity in healthy Japanese subjects. 2013/03
5. Original article　 Prostaglandin E(2) mediates acid-induced heartburn in healthy volunteers. 2013/03
6. Case report　 Successful Self-Expandable Metallic Stent Placement for a Case of Distal Rectal Stenosis due to Gastric Cancer Metastasis. 2013/05
7. Original article　 Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study. 2013/06
8. Original article　 Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front. 2013/10
9. Original article　 Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan. 2013/10
10. Original article　 A Randomized, Double-Blind, Placebo-Controlled Study of Rebamipide for Gastric Mucosal Injury Taking Aspirin With or Without Clopidogrel. 2014/03
11. Original article　 Effect of Rikkunshito on the expression of substance P and CGRP in dorsal root ganglion neurons and voluntary movement in rats with experimental reflux esophagitis 2014/04
12. Original article　 Helicobactor pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development 2014/05
13. Original article　 IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling. 2014/06
14. Original article　 Evaluation of Discomfort During Colonoscopy with Conventional and Ultrathin Colonoscopes in Ulcerative Colitis Patients. 2014/07
15. Case report　 Asymptomatic Free Air Caused by Mallory-Weiss Tears during Endoscopy 2015
16. Original article　 Effect of REG Iα protein on angiogenesis in gastric cancer tissues. 2015/05
17. Original article　 Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin. 2015/05
18. Introduction　 [Role of acid in functional dyspepsia]. 2015/07
19. Original article　 Junctional adhesion molecule-A promotes proliferation and inhibits apoptosis of gastric cancer. 2015/07
20. Original article　 The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers. 2015/07
21. Introduction　 PAR-2 activation enhances weak acid-induced ATP release through TRPV1 and ASICs sensitization in human esophageal epithelial cells. 2015/08
22. Original article　 Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study. 2015/09
23. Original article　 Morphological Characteristics of Early Gastric Neoplasms Detected After Helicobacter pylori Eradication. 2015/09
24. Introduction　 Histological diagnosis of gastric submucosal tumors: A pilot study of endoscopic ultrasonography-guided fine-needle aspiration biopsy vs mucosal cutting biopsy. 2015/10
25. Original article　 A randomized Phase II trial of systemic chemotherapy with and without trastuzumab followed by surgery in HER2-positive advanced gastric or esophagogastric junction adenocarcinoma with extensive lymph node metastasis: Japan Clinical Oncology Group study JCOG1301 (Trigger Study). 2015/11
26. Original article　 Impairment of gastric accommodation induced by water-avoidance stress is mediated by 5-HT2B receptors. 2016/02
27. Case report　 [Case Report; A case of esophageal achalasia diagnosed with HRM]. 2016/03
28. Case report　 Efficacy of Intrathecal MTX/Ara-C Combined with Systemic Chemotherapy in a Gastric Cancer Patient with Meningeal Carcinomatosis. 2016/03
29. Case report　 Efficacy of Intrathecal MTX/Ara-C Combined with Systemic Chemotherapy in a Gastric Cancer Patient with Meningeal Carcinomatosis. 2016/03
30. Original article　 Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model. 2016/03
31. Original article　 Esophageal Epithelial-Derived IL-33 Is Upregulated in Patients with Heartburn. 2016/05
32. Original article　 Localization of specialized intestinal metaplasia and the molecular alterations in Barrett esophagus in a Japanese population: an analysis of biopsy samples based on the"Seattle"biopsy protocol. 2016/05
33. Original article　 Prevalence of irritable bowel syndrome - like symptoms in Japanese patients with inactive inflammatory bowel disease. 2016/05
34. Original article　 Morphological Characteristics of Early Gastric Neoplasms Detected After Helicobacter pylori Eradication. 2016/06
35. Introduction　 Long journey to prevent metachronous gastric cancer after endoscopic resection 2016/07
36. Original article　 Prevalence and self-recognition of chronic constipation - Internet survey. 2016/07
37. Original article　 Role of regenerating gene I in claudin expression and barrier function in the small intestine. 2016/07
38. Original article　 What types of early gastric cancer are indicated for endoscopic ultrasonography staging of invasion depth? 2016/08
39. Original article　 Esophageal stricture after endoscopic submucosal dissection treated successfully by temporary stent placement. 2016/09
40. Original article　 Genetic instability, CpG island methylator phenotype, and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum. 2016/10 Link
41. Original article　 Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model. 2016/11
42. Original article　 Claudin-2 expression is upregulated in the ileum of diarrhea predominant irritable bowel syndrome patients. 2017/03
43. Original article　 Effect of Vonoprazan, a Potassium-Competitive Acid Blocker, on the (13)C-Urea Breath Test in Helicobacter pylori-Positive Patients. 2017/03
44. Original article　 Involvement of gut microbiota in association between GLP-1/GLP-1 receptor expression and gastrointestinal motility. 2017/04
45. Original article　 A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia. 2017/05
46. Original article　 Effect of Helicobacter pylori infection on the link between GLP-1 expression and motility of the gastrointestinal tract. 2017/05
47. Original article　 Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia. 2017/07
48. Original article　 Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? 2017/08
49. Original article　 Analysis of risk factors for colonic diverticular bleeding and recurrence. 2017/09
50. Original article　 Involvement of gut microbiota in the association between gastrointestinal motility and 5-HT expression/M2 macrophage abundance in the gastrointestinal tract. 2017/09
51. Original article　 A novel prostanoid EP1 receptor antagonist, ONO-8539, reduces acid-induced heartburn symptoms in healthy male volunteers: a randomized clinical trial. 2017/10
52. Original article　 Effects of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer. 2017/10
53. Original article　 Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals. 2017/10
54. Original article　 Association between gastrointestinal motility and macrophage/mast cell distribution in mice during the healing stage after DSS-induced colitis 2018/06
55. Original article　 Objective image analysis of non-magnifying image-enhanced endoscopy for diagnosis of small depressed early gastric cancers 2018/07
56. Original article　 Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats. 2018/08
57. Original article　 Filaggrin and tight junction proteins are crucial for IL-13-mediated esophageal barrier dysfunction. 2018/09
58. Original article　 Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population 2018/09
59. Original article　 New Approaches to Diagnosis and Treatment of Functional Dyspepsia 2018/10
60. Original article　 Randomised clinical trial: vonoprazan versus lansoprazole for the initial relief of heartburn in patients with erosive oesophagitis 2018/10
61. Original article　 Colonic M1 macrophage is associated with the prolongation of gastrointestinal motility and obesity in mice treated with vancomycin 2019/01
62. Original article　 Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center. Journal of Gastroenterology 2019/01
63. Original article　 Duodenal low-grade inflammation and expression of tight junction proteins in functional dyspepsia 2019/02
64. Original article　 Alteration of GLP-1/GPR43 expression and gastrointestinal motility in dysbiotic mice treated with vancomycin 2019/03
65. Original article　 Chenodeoxycholic Acid Releases Proinflammatory Cytokines from Small Intestinal Epithelial Cells Through the Farnesoid X Receptor. Digestion 2019/03
66. Introduction　 A Case of Severe Acute Gastritis as an Immune-Related Adverse Event After Nivolumab Treatment: Endoscopic and Pathological Findings in Nivolumab-Related Gastritis. 2021/07
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■ Presentation
1. Differences in esophageal perception between proximal and distal esophagus evaluated by electrical stimulation  2012/10/16
2. Clinical features of bamboo joint like appearance at the gastric body and cardia,notches in the duodenum with crohn,s disease  2013/01/26
3. Factors Affecting the Medical Consultation byDyspepsia in Japan  2013/03/02
4. Relationship between prevalence of IBS-like symptoms and quality of life in Japanese patients with Inactive Inflammatory Bowel disease  2013/03/02
5. Significant differences between proximal and distal esophagus in initial sensory thresholds and types of reported symptoms induced by electrical stimulation  2013/03/02
6. Groα promotes invasion of gastric cancer cells  2013/05/18
7. Childhood physical, sexual and psychological abuse are associated with the development of functional dyspepsia  2013/05/19
8. 5-HT2B receptor is involved in the regulation of gastric accommodation: A lesson from a model of gastric accommodation using conscious guinea pigs  2013/05/20
9. IBS-like symptoms in Japanese patients with inactive inflammatory bowel disease is associated with decreased quality of life  2013/05/20
10. TH2 cytokines induce the transdifferentiation of the normal human esophageal squamous cell toward columnar cell: A lesson from a stratified squamous epithelial model  2013/05/20
11. A randomized double-blind crossover placebo-controlled study to investigate the effect of nonsteroidal anti-inflammatory drug on acid-induced esophageal sensation in healthy volunteers  2013/05/21
12. Acidic deoxycholic acid and chenodeoxycholic acid induce interleukin-8 production through p38 MAPK and PKA: A lesson from a stratigied squamous esophageal epithelial model  2013/05/21
13. Both of esophageal visceral chemosensitivity and mechanosensitivity were similar in asymptomatic esophagitis(AE) and healthy subjects and were hypersensitive in non-erosive reflux disease(NERD)  2013/05/21
14. Cross-sectional study of the association between obesity and barrett's esophagus in a japanese population: A hospital-based prospective pilot study  2013/05/21
15. Down-regulation of submucosal claudin-18 involved in invasive and proliferative potential of gastric cancer  2013/08/03
16. Clinical outcomes and risk factors for perforation in gastric ESD:a prospective pilot study  2013/09/22
17. Expression of Reg family genes in the gastrointestinal tract injured by indomethacin  2013/09/23
18. Early satiety is a dyspeptic symptom associated with impaired gastric acoomodation in Japanese FD patients  2013/09/24
19. A typical symptoms and HRQOL of patients with asymptomatic GERD is asymptomatic GERD really silent?  2013/09/27
20. IL-4 induces columnar differentiation of esophageal squamous epithelium through JAK/PI3K pathway: A possible role in the pathogenesis of barrett's esophagus  2013/09/27
21. Down-regulation of claudin-1815 associated with proliferative and invasive potential of gastric cancer at the invasive front  2013/10/16
22. IL-33 in the pathogenesis of gastroesophageal reflux disease  2014/02/15
23. Intra-venous Corticotropin Releaseing Hormone(CRH) administration increased esophageal electrical sensitivity in normal subjects  2014/05/05
24. Junctional adhesion molecule-a is a contributing factor for gastric cancer cell proliferation and invation  2014/05/06
25. Effects of nizatidine and famotidine on gastric mitility in healthy volunteers -a randomized crossover trial  2014/09/06
26. Efficacy of serotonin type3 receptor antagonist ramosetron in the treatment of diarrhea-predominant irritable bowel syndrome with inactive Crohn's disease, a pilot trial  2014/09/06
27. Association between obesity and barrett's esophagus in a Japanese population  2014/09/23
28. Esophageal epithelial-derived intracellular IL-33 exaggerates inflammation in the pathogenesis of reflux esophagitis  2014/09/23
29. Prevalence and Self-Recognition of Sonstipation in Japanese Population  2015/02/08
30. Regulation of Esophageal Epithelial-derived Cytokines by IL-33  2015/02/08
31. IBS symptoms in IBD remission  2015/03/05
32. Prevalence and self-recognition of chronic constipation-internet survey in Japan  2015/03/06
33. TRPV1 and ASICs exacerbate acid-induced ATP release through PAR-2 activation  2015/04/24
34. Non-Magnifying Narrow-Band Imaging of Small Intramucosal Signet Ring Cell Carcinoma of the Stomach  2015/05/16
35. Effect of REG Protein on Mucosal Permeability and Adhesion Molecule Expression in the Small Intestine  2015/05/17
36. Evaluation of Discomfort During Colonoscopy With a New Ultrathin Flexible Colonoscope in Crohn's Disease. A Randomized Controlled Trial  2015/05/17
37. Histological Diagnosis of Gastric Submucosal tumors: Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy vs. Mucosal Cutting Biops  2015/05/18
38. PAR-2 Activation Enhances Acid-Induced ATP Release Through TRPV1 and ASICs Sensitization in Human Esophageal Epithelial Cells  2015/05/18
39. Upregulation and the Regulation of Esophageal Epithelial-Derived IL-33 in Non-Erosive Reflux Disease  2015/05/18
40. Acotiamide Improves Dtress-Induced Impaired Gastric Accommodation  2015/05/19
41. Case Series of Laparoscopic Assisted Endoscopic Submucosal Dissection (LAESD)  2015/05/19
42. Effect of H.pylori infection on GLP-1 expression and gastrointestinal motility  2015/12/05
43. Possibility of EMR/ESD as a diagnostic therapy for colorectal neoplasms in association with ulcerative colitis  2015/12/05
44. Upper gastrointestinal symptoms in patients with gastroduodenal ulcers: Use of non-steroidal anti-inflammatory drugs and low-dose aspirin  2015/12/06
45. Adenosine Triphosphate-Induced Purinergic Receptor Activation and Proinflammatory Cytokine Release in Human Esophageal Epithelial Multilayer Cells  2016/05/22
46. Involvement of Gut Microbiota in the Association Between Macrophage and Gastrointestinal Motility  2016/05/22
47. The Role of Serotonin in Reflux-Induced Esophageal Mucosal Injury in Human Esophageal Epithelial Cells  2016/05/22
48. A Double-Blind Placebo Controlled Study of Acotiamide Hydrochloride for Efficacy on Gastrointestinal Motility of Patients With Functional Dyspepsia  2016/05/23
49. Is the Symptoms of NSAIDs Ulcer Truly Milder Than That of Ordinary Ulcer?  2016/05/23
50. Effect of REG Protein on the Link Claudin Expression and Mucosal Permeability in the Small Intestine  2016/05/24
51. Effect of Vonoprazan, a Potassium-Competitive Acid Blocker, on the 13C Urea Breath Test in H. pylori-Positive Japanese Patients  2016/05/24
52. Localization of Specialized Intestinal Metaplasia and the Molecular Alterations and Cellular Phenotype in Barrett's Esophagus in a Japanese Population: An Analysis Based on the "Seattle" Biopsy Protocol  2016/05/24
53. A randomized phase II trial of systemic chemotherapy with or without trastuzumab followed by surgery in HER2 positive advanced gastric or esophagogastric junction adenocarcinoma with extensive lymph node metastasis: Japan Clinical Oncology Group study JCOG1301C (Trigger study).  2016/06/04
54. Alteration of gastrointestinal motility and mast cell behavior in mice after DSS-induced colitis  2016/08/26
55. Diagnostic value of constipation in the Japanese population, using the Rome III criteria and definitions from the Japanese Society of Internal Medicine  2016/08/26
56. Esophageal epithelial IL-33 is up-regulated in patients with non-erosive reflux disease  2016/08/27
57. Comparison of molecular alterations and proliferative activity between diminutive and small tubular adenoma of the colorectum  2016/11/03
58. Comparison of suitability of three snares with various hardness for cold snare polypectomy  2016/11/03
59. Association between mast cell and gastrointestinal motility in mice after DSS-induced cilitis  2016/11/04
60. Evalution of the diagnostic performance of colon capsule endoscopy for colon polyps in Hyogo college of Medicine  2016/11/05
61. The baseline ratio of neutrophils to lymphocytes is associated with outcome of paclitaxel plus ramucirumab treated metastatic or unresectable locally advanced gastric adenocarcinoma  2016/11/05
62. Prevalence of gastric motility disorders in patients with PDS type functional dyspepsia  2017/03/23
63. Role of dysmotility in functional dyspepsia and efficacy of acotiamide  2017/03/23
64. Association between Clostridium difficile infection and acid suppression: A systematic review and meta-analysis  2017/03/24
65. Effect of gut microbiota on Reg Illr expression in relation to intestinal immunity  2017/03/24
66. Investigation of esophageal epithelial function using 3D culture system  2017/03/24
67. Role of gut microbiota on GLP-1 receptor expression and gastrointestinal motility  2017/03/24
68. Low-grade inflammation and epithelial junctional proteins of duodenal mucosa in functional dyspepsia  2017/03/25
69. The duodenum, a new target for research  2017/03/25
70. A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel  2017/04/27
71. Are the symptoms of an NSAIDs-induced ulcer truly milder than those of an ordinary ulcer?  2017/04/27
72. Involvement of gut microbiota in Reg IIIg expression in the intestinal mucosa  2017/04/28
73. Involvement of H. pylori infection in PAX6/GLP-1 expression and gastrointestinal motility  2017/04/28
74. Analysis of Risk Factors for Colonic Diverticular Bleeding and Recurrence.  2017/05/06
75. Ratio of Neutrophil to Lymphocytes is Useful to Predict the Prognosis of Patients with Paclitaxel Plus Ramucirumab Treatment for Unresectable Advanced Gastric Cancer.  2017/05/06
76. Associations Among Adiposity, Mediating Biomarkers and Colorectal Adenomatous Polyps Risk in a Japanese Population  2017/05/08
77. Relationship between Intestinal Motility and Small Intestinal Inflammation after acut E.colitis.  2017/05/08
78. Upregulation of Esophageal Prostaglandin E2 Levels in Patients with Heartburn.  2017/05/08
79. Duodenal Low-Grade Inflammation and Tight Junction Proteins in Functional Dyspepsia.  2017/05/09
80. Filaggrin and Tight Junction Proteins are Crucial for Esophageal Mucosal Barrier in Eosinophilic Esophagitis.  2017/05/09
81. Magnitude and Nature of Association between Clostridium Difficile Infection and Acid Suppression: A Systematic Literature Review and Meta-Analysis.  2017/05/09
82. Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia.  2017/05/09
83. Long-term effects of H. pylori eradication on molecular alterations related to gastric carcinogenesis.  2017/10/31
84. Antibiotics treatment prolongs gastrointestinal transit time accompanted by increase of colonic GLP-1/GPR43 expression.  2018/06/02
85. Long-term effects of H. pylori eradication on molecular alterations in precancerous lesions, atrophic mucosa and intestinal metaolasia.  2018/06/02
86. Double-blind, randomized trial of effects of vonoprazan and lansoprazole for the first seven days on relief of gastroesophageal reflux disease symtopms.  2018/06/03
87. Combination of neutrophil-to-lymphocyte ratio (NTR) and G8 screening tool is useful to predict overall survival of elderly patients with chemotherapy for unresectable/recurrent gastric cancer.  2018/06/05
88. A present status of the treatment for constipation before and after the publication of the clinical guidelines of chronic constipation in Japan.  2018/07/05
89. A randomized double-blind placebo controlled trial on the effect of magnesium oxide in patients with chronic constipation.  2018/07/05
90. Effect of vancomycin treatment on colonic GLP-1/GRP 43 expression and gastrointestinal transit time.  2018/07/05
91. Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population.  2018/07/05
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