Faculty Information |
|
Language | Japanese |
The announcement title | Tetrabenazine attenuates morphine-induced hyperlocomotion in mice |
Conference Type | Domestic Society |
Announcement form | Poster presentation |
Presentation Type | General Lecture |
Lecture Type | General Lecture |
Date | 2017/03/16 |
Description | A single administration of mice with morphine (30 mg/kg, i.p.) induced a long-lasting hyperlocomotion. Pretreatment of mice with a benzoquinolizine derivative tetrabenazine (TBZ; a reversible vesicular monoamine transporter 2 inhibitor) (1 mg/kg) for 30 min showed a significant reduction of the hyperlocomotion induced by morphine, as compared with saline-pretreated subjects. No significant change in locomotion was observed in mice pretreated with TBZ alone. TBZ at a dose of 1 mg/kg inhibited a dopamine turnover (a ratio of HVA/dopamine) in the cerebral cortex. In contrast, pretreatment with TBZ had no effect on morphine-induced antinociception evaluated by tail flick and hot plate tests. These observations suggest that pretreatment with TBZ attenuates morphine-induced hyperlocomotion, but not antinociception, via an inhibition of cerebral cortical dopamine turnover. |