Faculty Information |
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Language | Japanese |
The announcement title | The central and peripheral effects of memantine in mice |
Conference Type | Domestic Society |
Announcement form | Poster presentation |
Presentation Type | General Lecture |
Lecture Type | General Lecture |
Date | 2017/03/16 |
Description | A single administration of mice with memantine, the NMDA receptor antagonist, induced stereotyped behaviors in dose- and time-dependent manners. The predominant component of the stereotypy was a continuous, exaggerated sniffing. In contrast, a psychostimulant methamphetamine (METH) predominantly induced a stereotyped biting. The memantine-induced stereotyped sniffing was attenuated by pretreatment with haloperidol, a dopamine D2 receptor antagonist, and betahistine, an agent for treatment of vertigo associated with Ménière's disease which is an analogue of histamine with weak agonist properties at histamine H1 receptors and more potent anatgonistic effects at histamine H3 receptors. Heart rate and systolic blood pressure were monitored at frequent intervals using a tail-cuff microsensor device. No altered heart rate and blood pressure were observed in mice treated with memantine (5 mg/kg) as compared control animals. These observations suggest that memantine induced stereotypies via unknown mechanisms which may be different from those of METH, while memantine is not likely to exhibit peripheral effects. |