Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Involvement of YKL-40-positive macrophages commonly identified in polymyositis and dermatomyositis in the pathogenesis of myositis: a retrospective study. |
Journal | Formal name:Immunological medicine ISSN code:25785826 |
Volume, Number, Page | 47,pp.37-44 |
Papers・Author | Noguchi Kazuteru, Furukawa Tetsuya, Tatsumi Yoshiki, Kasama Shuhei, Yoshikawa Takahiro, Hashimoto Teppei, Azuma Naoto, Hirota Seiichi, Kimura Takashi, Matsui Kiyoshi. |
Publication date | 2024/03 |
Papers・Description | YKL-40 is implicated in inflammation and tissue repair, but no reports have investigated its involvement in myositis in polymyositis (PM) and dermatomyositis (DM). Therefore, we aimed to investigate the relationship between YKL-40 and PM/DM. We retrospectively enrolled 35 patients diagnosed with PM/DM along with 26 healthy controls (HCs). Both PM and DM were diagnosed according to Bohan and Peter's criteria. Serum YKL-40 levels were measured, age-corrected to YKL-40 percentile values, and compared to HCs. Patients with myositis without interstitial lung disease were also enrolled and compared to HCs. Immunofluorescence staining was performed to identify YKL-40-positive inflammatory cells in muscle biopsy samples from two patients each with PM and DM. Age-corrected serum YKL-40 levels were significantly higher in patients with PM/DM compared to HCs with and without lung disease; however, these levels decreased significantly after treatment. |