教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Involvement of YKL-40-positive macrophages commonly identified in polymyositis and dermatomyositis in the pathogenesis of myositis: a retrospective study. |
掲載誌名 | 正式名:Immunological medicine ISSNコード:25785826 |
巻・号・頁 | 47,pp.37-44 |
著者・共著者 | Noguchi Kazuteru, Furukawa Tetsuya, Tatsumi Yoshiki, Kasama Shuhei, Yoshikawa Takahiro, Hashimoto Teppei, Azuma Naoto, Hirota Seiichi, Kimura Takashi, Matsui Kiyoshi. |
発行年月 | 2024/03 |
概要 | YKL-40 is implicated in inflammation and tissue repair, but no reports have investigated its involvement in myositis in polymyositis (PM) and dermatomyositis (DM). Therefore, we aimed to investigate the relationship between YKL-40 and PM/DM. We retrospectively enrolled 35 patients diagnosed with PM/DM along with 26 healthy controls (HCs). Both PM and DM were diagnosed according to Bohan and Peter's criteria. Serum YKL-40 levels were measured, age-corrected to YKL-40 percentile values, and compared to HCs. Patients with myositis without interstitial lung disease were also enrolled and compared to HCs. Immunofluorescence staining was performed to identify YKL-40-positive inflammatory cells in muscle biopsy samples from two patients each with PM and DM. Age-corrected serum YKL-40 levels were significantly higher in patients with PM/DM compared to HCs with and without lung disease; however, these levels decreased significantly after treatment. |