Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Assessing Therapeutic Response to Radium-223 with an Automated Bone Scan Index among Metastatic Castration-Resistant Prostate Cancer Patients: Data from Patients in the J-RAP-BSI Trial. |
Journal | Formal name:Cancers ISSN code:20726694 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 15(10),pp.2784 |
Papers・Author | Kitajima Kazuhiro, Kuyama Junpei, Kawahara Takashi, Suga Tsuyoshi, Otani Tomoaki, Sugawara Shigeyasu, Kono Yumiko, Tamaki Yukihisa, Seko-Nitta Ayumi, Ishiwata Yoshinobu, Ito Kimiteru, Toriihara Akira, Watanabe Shiro, Hosono Makoto, Miyake Hideaki, Yamamoto Shingo, Sasaki Ryohei, Narita Mitsuhiro, Yamakado Koichiro |
Publication date | 2023/05 |
Papers・Description | To evaluate the usefulness of change in the automated bone scan index (aBSI) value derived from bone scintigraphy findings as an imaging biomarker for the assessment of treatment response and survival prediction in metastatic castration-resistant prostate cancer (mCRPC) patients treated with Ra-223. This study was a retrospective investigation of a Japanese cohort of 205 mCRPC patients who received Ra-223 in 14 hospitals between July 2016 and August 2020 and for whom bone scintigraphy before and after radium-223 treatment was available. Correlations of aBSI change, with changes in the serum markers alkaline phosphatase (ALP) and prostate-specific antigen (PSA) were evaluated. Additionally, the association of those changes with overall survival (OS) was assessed using the Cox proportional-hazards model and Kaplan-Meier curve results. ... |
DOI | 10.3390/cancers15102784 |
PMID | 37345121 |