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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Sustained remission following the discontinuation of tofacitinib in patients with rheumatoid arthritis (XANADU study): an open-label randomised study.
掲載誌名	正式名：RMD open ISSNコード：20565933
掲載区分	国外
巻・号・頁	9(2)
著者・共著者	Kubo Satoshi, Miyazaki Yusuke, Amano Koichi, Matsui Kiyoshi, Kameda Hideto, Inoue Yoshino, Nakayamada Shingo, Ogura Takehisa, Kaneko Yuko, Yamaoka Kunihiro, Tanaka Yoshiya.
発行年月	2023/04
概要	OBJECTIVE: To investigate sustained remission following the discontinuation of tofacitinib in patients with rheumatoid arthritis. METHODS: Patients who had an inadequate response to methotrexate (MTX) with or without biological disease-modifying antirheumatic drugs were randomly divided into two groups at baseline, and tofacitinib treatment in combination with MTX was administered to both groups. Either MTX or tofacitinib was then withdrawn if patients achieved Clinical Disease Activity Index remission at week 52. The primary outcome was the proportion of patients who sustained clinical remission at week 104. RESULTS: A total of 113 patients participated in this study. Among them, a total of 48 patients achieved remission at week 52. After discontinuation of tofacitinib, only 29.2% (7/24) of patients remained remission, while 50.0% (10/20) of patients, which was numerically higher but not statistically significant, sustained remission after MTX discontinuation.