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Article types	Original article
Language	English
Refereed paper	Refereed
Title	Association between hypogammaglobulinaemia and severe infections during induction therapy in ANCA-associated vasculitis: from J-CANVAS study.
Journal	Formal name：Rheumatology (Oxford, England) ISSN code：14620332/14620324
Domestic / Foregin	Foregin
Papers・Author	Omura Satoshi, Kida Takashi, Noma Hisashi, Sunaga Atsuhiko, Kusuoka Hiroaki, Kadoya Masatoshi, Nakagomi Daiki, Abe Yoshiyuki, Takizawa Naoho, Nomura Atsushi, Kukida Yuji, Kondo Naoya, Yamano Yasuhiko, Yanagida Takuya, Endo Koji, Hirata Shintaro, Matsui Kiyoshi, Takeuchi Tohru, Ichinose Kunihiro, Kato Masaru, Yanai Ryo, Matsuo Yusuke, Shimojima Yasuhiro, Nishioka Ryo, Okazaki Ryota, Takata Tomoaki, Ito Takafumi, Moriyama Mayuko, Takatani Ayuko, Miyawaki Yoshia, Ito-Ihara Toshiko, Yajima Nobuyuki, Kawaguchi Takashi, Fukuda Wataru, Kawahito Yutaka.
Publication date	2023/03
Papers・Description	OBJECTIVES: To investigate the association between decreased serum IgG levels caused by remission-induction immunosuppressive therapy of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and the development of severe infections. METHODS: We conducted a retrospective cohort study of patients with new-onset or severe relapsing AAV enrolled in the J-CANVAS registry, which was established at 24 referral sites in Japan. The minimum serum IgG levels up to 24 weeks and the incidence of severe infection uweeks after treatment initiation were evaluated. After multiple imputations for all explanatory variables, we performed the multivariate analysis using a Fine-Gray model to assess the association between low IgG (the minimum IgG levels < 500 mg/dl) and severe infections. In addition, the association was expressed as a restricted cubic spline (RCS) and analysed by treatment subgroups.