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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Tocilizumab suppresses NF-kappa B activation via toll-like receptor 9 signaling by reducing cell-free DNA in rheumatoid arthritis.
掲載誌名	正式名：Clinical and experimental immunology ISSNコード：13652249/00099104/00099104
掲載区分	国外
巻・号・頁	213,pp.209-220
著者・共著者	Hashimoto Teppei, Yoshida Kohsuke, Yokoyama Yuichi, Hashimoto Naonori, Kaneshiro Kenta, Yoshikawa Takahiro, Tateishi Koji, Terashima Yasuhiro, Matsui Kiyoshi, Hashiramoto Akira.
発行年月	2023/07
概要	Endogenous DNA is released into the bloodstream as cell-free DNA (cfDNA) following cell death and is associated with various pathological conditions. However, their association with therapeutic drugs against rheumatoid arthritis (RA) remains unknown. Therefore, we investigated the significance of cfDNA in RA treated with tocilizumab and tumour necrosis factor inhibitor (TNF-I). Biological DMARDs (bDMARDs), including tocilizumab and TNF-I, were administered to 77 and 59 RA patients, respectively. Plasma cfDNA levels were measured at weeks 0, 4, and 12 by quantitative polymerase chain reaction. Disease activity was evaluated at the same time point using DAS28ESR. cfDNA levels from RA synovial cells treated with tocilizumab or etanercept for 24 h were measured.