Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Effect of Muscle Loss but Not Fat Loss during Primary Debulking Surgery and Chemotherapy on Prognosis of Patients with Ovarian Cancer. |
Journal | Formal name:Journal of clinical medicine Abbreviation:J Clin Med ISSN code:20770383/20770383 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 11(11),pp.11 |
Papers・Author | Nakayama Naomi, Nakayama Kentaro, Ishibashi Tomoka, Katayama Satoru, Kyo Satoru |
Publication date | 2022/06 |
Papers・Description | Although the negative effect of muscle loss during invasive treatment has been widely reported in patients with cancer, its value in patients with ovarian cancer is not clear. Therefore, this study was conducted to clarify whether muscle loss during cytoreductive surgery and chemotherapy affects prognosis in patients with ovarian cancer. We retrospectively recruited 58 patients with ovarian cancer who underwent site reductive surgery and chemotherapy at Shimane University Hospital from March 2006 to November 2013 and for whom pre- and postoperative computed tomography were available. Skeletal muscle changes and fat mass volume during primary debulking surgery and chemotherapy were subsequently investigated at the level of the third lumbar vertebra. Muscle and fat mass loss occurred independently in half of the patients. Muscle loss, but not fat loss, was associated with disease-free survival (p = 0.041 and p = 0.794, respectively) and poor overall survival (p = |
DOI | 10.3390/jcm11113184 |
PMID | 35683568 |