Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Clinical Utility of Germline Genetic Testing in Japanese Men Undergoing Prostate Biopsy. |
Journal | Formal name:JNCI cancer spectrum ISSN code:25155091 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 6(1),pp.pkac001 |
Papers・Author | Akamatsu Shusuke, Terada Naoki, Takata Ryo, Kinoshita Hidefumi, Shimatani Kimihiro, Momozawa Yukihide, Yamamoto Michio, Tada Harue, Kawamorita Naoki, Narita Shintaro, Kato Takuma, Nitta Masahiro, Kandori Shuya, Koike Yusuke, Inazawa Johji, Kimura Takahiro, Kimura Hiroko, Kojima Takahiro, Terachi Toshiro, Sugimoto Mikio, Habuchi Tomonori, Arai Yoichi, Yamamoto Shingo, Matsuda Tadashi, Obara Wataru, Kamoto Toshiyuki, Inoue Takahiro, Nakagawa Hidewaki, Ogawa Osamu |
Publication date | 2022/02 |
Papers・Description | BACKGROUND: Multiple common variants and also rare variants in monogenic risk genes such as BRCA2 and HOXB13 have been reported to be associated with risk of prostate cancer (PCa); however, the clinical setting in which germline genetic testing could be used for PCa diagnosis remains obscure. Herein, we tested the clinical utility of a 16 common variant-based polygenic risk score (PRS) that has been developed previously for Japanese men and also evaluated the frequency of PCa-associated rare variants in a prospective cohort of Japanese men undergoing prostate biopsy. |
DOI | 10.1093/jncics/pkac001 |
PMID | 35118230 |