|A global perspective on improving patient care in uncomplicated urinary tract infection: expert consensus and practical guidance.
|Formal name：Journal of global antimicrobial resistance
|Domestic / Foregin
|Volume, Number, Page
|Wagenlehner Florian, Nicolle Lindsay, Bartoletti Riccardo, Gales Ana C, Grigoryan Larissa, Huang Haihui, Hooton Thomas, Lopardo Gustavo, Naber Kurt, Poojary Aruna, Stapleton Ann, Talan David A, Saucedo José Tirán, Wilcox Mark H, Yamamoto Shingo, Yang Stephen S, Lee Seung-Ju
|OBJECTIVES: Uncomplicated urinary tract infections (uUTIs) are a common problem in female patients. Management is mainly based on empirical prescribing, but there are concerns about overtreatment and antimicrobial resistance (AMR), especially in patients with recurrent uUTIs. METHODS: A multidisciplinary panel of experts met to discuss diagnosis, treatment, prevention, guidelines, AMR, clinical trial design and the impact of COVID-19 on clinical practice. RESULTS: Symptoms remain the cornerstone of uUTI diagnosis, and urine culture is necessary only when empirical treatment fails or rapid recurrence of symptoms or AMR is suspected. Specific antimicrobials are first-line therapy (typically nitrofurantoin, fosfomycin, trimethoprim/sulfamethoxazole and pivmecillinam, dependent on availability and local resistance data). Fluoroquinolones are not first-line options for uUTIs primarily due to safety concerns but also rising resistance rates. ..