Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Marginal zone B cells acquire dendritic cell functions by trogocytosis. |
Journal | Formal name:Science (New York, N.Y.) ISSN code:10959203/00368075 |
Domestic / Foregin | Foregin |
Publisher | アメリカ科学振興協会 |
Volume, Number, Page | 375,pp.eabf7470 |
Papers・Author | Patrick Schriek, Alan C Ching, Nagaraj S Moily, Jessica Moffat, Lynette Beattie, Thiago M Steiner, Laine M Hosking, Joshua M Thurman, V Michael Holers, Ishido Satoshi, Mireille H Lahoud, Irina Caminschi, William R Heath, Justine D Mintern, Jose A Villadangos. |
Publication date | 2022/02 |
Papers・Description | Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, antibody production requires MZ B cells to display pathogen antigens bound to major histocompatibility complex class II (MHC II) molecules to T cells. We describe the trogocytic acquisition of these molecules from conventional dendritic cells (cDCs). Complement component 3 (C3) binds to murine and human MHC II on cDCs. MZ B cells recognize C3 with complement receptor 2 (CR2) and trogocytose the MHC II-C3 complexes, which become exposed on their cell surface. The ubiquitin ligase MARCH1 limits the number of MHC II-C3 complexes displayed on cDCs to prevent their elimination through excessive trogocytosis. Capture of C3 by MHC II thus enables the transfer of cDC-like properties to MZ B cells. |