Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Basal Plasma Aldosterone Concentration Predicts Therapeutic Outcomes in Primary Aldosteronism. |
Journal | Formal name:Journal of the Endocrine Society ISSN code:24721972 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 4,pp.bvaa011 |
Papers・Author | Aya Saiki, Michio Otsuki, Kosuke Mukai, Reiko Hayashi , Iichiro Shimomura , Isao Kurihara , Takamasa Ichijo , Yoshiyu Takeda , Takuyuki Katabami , Mika Tsuiki , Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone , Nobuya Inagaki, Takanobu Yoshimoto, Ryuji Okamoto, Katsutoshi Takahashi , Hiroki Kobayashi , Kouichi Tamura, Kohei Kamemura, Koichi Yamamoto , Shoichiro Izawa , Miki Kakutani , Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse |
Publication date | 2020/04 |
Papers・Description | PURPOSE: Normal basal plasma aldosterone concentration (PAC) reflects mild aldosterone excess compared to high basal PAC. We previously reported lower risk for cardiovascular and cerebrovascular events in patients with primary aldosteronism (PA) and normal basal PAC (nPA) than in those with high basal PAC (hPA). However, the differences in therapeutic outcomes between nPA and hPA are unclear. The aim of this multi-institutional, retrospective cohort study was to determine the clinical significance of nPA to therapeutic outcomes, including adrenalectomy (ADX) and treatment with mineralocorticoid receptor antagonists (MRAs). METHODS: A total of 1146 patients with PA who were diagnosed and underwent adrenal venous sampling (AVS) between January 2006 and October 2016 were enrolled. The clinical parameters at baseline and after ADX or treatment with MRA were compared between the nPA and hPA groups. RESULTS: |