Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Underlying diseases in sporadic presentation of high creatine kinase levels in girls. |
Journal | Formal name:Clinica chimica acta; international journal of clinical chemistry ISSN code:18733492/00098981 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 519,pp.198-203 |
Papers・Author | Lee T, Tokunaga S, Taniguchi N, Misaki M, Shimomura H, Nishino I, Itoh K, Takeshima Y |
Publication date | 2021/08 |
Papers・Description | Identifying the causes of hyperCKemia is crucial for enabling appropriate follow-up and care. This study aimed to elucidate the underlying causes of high CK levels in girls. Fourteen girls (seven symptomatic, seven asymptomatic) with persistently elevated CK levels but without a family history of muscle diseases were referred to our hospital between April 2014 and August 2018. Among the symptomatic girls, six (85.7%) had muscular dystrophy (five DMD/BMD carriers, and one sarcoglycanopathy [limb-girdle muscular dystrophy: LGMDR4]), and one had dermatomyositis. Among the asymptomatic girls, four (57.1%) had muscular dystrophy (three DMD/BMD carriers, and one calpainopathy [LGMDR1]), and three were undiagnosed. Our results indicate that muscular dystrophy, including DMD/BMD carriers, must be considered in girls with highperCKemia regardless of symptoms presentation, and in symptomatic girls with dermatomyositis. |