教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Underlying diseases in sporadic presentation of high creatine kinase levels in girls. |
掲載誌名 | 正式名:Clinica chimica acta; international journal of clinical chemistry ISSNコード:18733492/00098981 |
掲載区分 | 国外 |
巻・号・頁 | 519,pp.198-203 |
著者・共著者 | Lee T, Tokunaga S, Taniguchi N, Misaki M, Shimomura H, Nishino I, Itoh K, Takeshima Y |
発行年月 | 2021/08 |
概要 | Identifying the causes of hyperCKemia is crucial for enabling appropriate follow-up and care. This study aimed to elucidate the underlying causes of high CK levels in girls. Fourteen girls (seven symptomatic, seven asymptomatic) with persistently elevated CK levels but without a family history of muscle diseases were referred to our hospital between April 2014 and August 2018. Among the symptomatic girls, six (85.7%) had muscular dystrophy (five DMD/BMD carriers, and one sarcoglycanopathy [limb-girdle muscular dystrophy: LGMDR4]), and one had dermatomyositis. Among the asymptomatic girls, four (57.1%) had muscular dystrophy (three DMD/BMD carriers, and one calpainopathy [LGMDR1]), and three were undiagnosed. Our results indicate that muscular dystrophy, including DMD/BMD carriers, must be considered in girls with highperCKemia regardless of symptoms presentation, and in symptomatic girls with dermatomyositis. |