教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Risk prediction for metastasis of clear cell renal cell carcinoma using digital multiplex ligation-dependent probe amplification. |
掲載誌名 | 正式名:Cancer science ISSNコード:13497006/13479032 |
掲載区分 | 国内 |
巻・号・頁 | 113(1),pp.297-307 |
著者・共著者 | Yoshikawa Yoshie, Yamada Yusuke, Emi Mitusru, Lilit Atanesyan, Jan Smout, Karel de Groot, Suvi Savola, Nakanishi-Shinkai Yukako, Kanematsu Akihiro, Nojima Mmichio, Ohmuraya Masaki, Hashimoto-Tamaoki Tomoko, Yamamoto Shingo |
発行年月 | 2022/01 |
概要 | Precise quantification of copy-number alterations (CNAs) in a tumor genome is difficult. We have applied a comprehensive copy-number analysis method, digital multiplex ligation-dependent probe amplification (digitalMLPA), for targeted gene copy-number analysis in clear cell renal cell carcinoma (ccRCC). Copy-number status of all chromosomal arms and 11 genes was determined in 60 ccRCC samples. Chromosome 3p loss and 5q gain, known as early changes in ccRCC development, as well as losses at 9p and 14q were detected in 56/60 (93.3%), 31/60 (51.7%), 11/60 (18.3%), and 33/60 (55%), respectively. |
文献番号 | 2023067999 |
PMID | 34687579 |