教員業績データベース |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | CD44 expression in stem cells and niche microglia/macrophages following ischemic stroke. |
掲載誌名 | 正式名:Stem cell investigation 略 称:Stem Cell Investig ISSNコード:2306975923069759 |
巻・号・頁 | 7,pp.4 |
著者・共著者 | Sawada Rikako, Nakano-Doi Akiko, Matsuyama Tomohiro, Nakagomi Nami, Nakagomi Takayuki |
発行年月 | 2020/03 |
概要 | Background:CD44, an adhesion molecule in the hyaluronate receptor family, plays diverse and important roles in multiple cell types and organs. Increasing evidence is mounting for CD44 expression in various types of stem cells and niche cells surrounding stem cells. However, the precise phenotypes of CD44+Methods:In the present study, using a mouse model for cerebral infarction by middle cerebral artery (MCA) occlusion, we examined the localization and traits of CD44+Results:In sham-mice operations, CD44 was rarely observed in the cortex of MCA regions. Following ischemic stroke, CD44+Conclusions:These data demonstrate that CD44 is expressed in stem cells and cells in the niches surrounding them, including inflammatory cells, suggesting that CD44 may play an important role in reparative processes within ischemic areas under neuroinflammatory conditions; in particular, strokes. |
DOI | 10.21037/sci.2020.02.02 |
PMID | 32309418 |