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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Roles of Autophagy and Pancreatic Secretory Trypsin Inhibitor in Trypsinogen Activation in Acute Pancreatitis.
掲載誌名	正式名：Pancreas 略　 称：Pancreas ISSNコード：1536482808853177
掲載区分	国外
巻・号・頁	49(4),pp.493-497
著者・共著者	Hirota Masahiko, Ohmuraya Masaki, Hashimoto Daisuke, Suyama Koichi, Sugita Hiroki, Ogawa Michio
発行年月	2020/04
概要	The focus of the review is on roles of autophagy and pancreatic secretory trypsin inhibitor (PSTI), an endogenous trypsin inhibitor, in trypsinogen activation in acute pancreatitis. Acute pancreatitis is a disease in which tissues in and around the pancreas are autodigested by pancreatic digestive enzymes. This reaction is triggered by the intrapancreatic activation of trypsinogen. Autophagy causes trypsinogen and cathepsin B, a trypsinogen activator, to colocalize within the autolysosomes. Consequently, if the resultant trypsin activity exceeds the inhibitory activity of PSTI, the pancreatic digestive enzymes are activated, and they cause autodigestion of the acinar cells. Thus, autophagy and PSTI play important roles in the development and suppression of acute pancreatitis, respectively.
DOI	10.1097/MPA.0000000000001519
PMID	32282761