教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice. |
掲載誌名 | 正式名:Hypertension (Dallas, Tex. : 1979) 略 称:Hypertension ISSNコード:152445630194911X |
掲載区分 | 国外 |
巻・号・頁 | 75(2),pp.413-21 |
著者・共著者 | Yasumura Seiki, Naito Yoshiro, Okuno Keisuke, Sawada Hisashi, Asakura Masanori, Masuyama Tohru, Ishihara Masaharu |
発行年月 | 2020/02 |
概要 | Renal fibrosis is the final pathological process common for several types of end-stage renal diseases, including obstructive nephropathy and diabetic kidney disease. Substantial renal iron loads and oxidative stress have been reported to contribute to the development of renal diseases. TfR1 (transferrin receptor 1) plays a crucial role in cellular iron transport. However, there are no studies investigating TfR1 in the pathophysiology of renal fibrosis. Here, we investigate the role of TfR1 in the development of renal fibrosis. Primarily, to ascertain an association of TfR1 in the pathophysiology of renal fibrosis, we induced unilateral ureteral obstruction in wild-type (WT) and heterozygous TfR1 deleted (TfR1 |
DOI | 10.1161/HYPERTENSIONAHA.119.13670 |
PMID | 31838906 |