教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor. |
掲載誌名 | 正式名:Frontiers in immunology 略 称:Front Immunol ISSNコード:1664322416643224 |
掲載区分 | 国外 |
巻・号・頁 | 10,pp.2212 |
著者・共著者 | Ozasa Koji, Temizoz Burcu, Kusakabe Takato, Kobari Shingo, Momota Masatoshi, Coban Cevayir, Ito Shuichi, Kobiyama Kouji, Kuroda Etsushi, Ishii Ken J |
発行年月 | 2019/09 |
概要 | Extracellular host-derived DNA, as one of damage associated molecular patterns (DAMPs), is associated with allergic type 2 immune responses. Immune recognition of such DNA generates the second messenger cyclic GMP-AMP (cGAMP) and induces type-2 immune responses; however, its role in allergic diseases, such as asthma, has not been fully elucidated. This study aimed to determine whether cGAMP could induce asthma when used as an adjuvant. We intranasally sensitized mice with cGAMP together with house dust mite antigen (HDM), followed by airway challenge with HDM. We then assessed the levels of eosinophils in the broncho-alveolar lavage fluid (BALF) and serum HDM-specific antibodies. cGAMP promoted HDM specific allergic asthma, characterized by significantly increased HDM specific IgG1 and total IgE in the serum and infiltration of eosinophils in the BALF. cGAMP stimulated lung fibroblast cells to produce IL-33in vitro |
DOI | 10.3389/fimmu.2019.02212 |
PMID | 31616416 |