教員業績データベース |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia. |
掲載誌名 | 正式名:Scientific reports 略 称:Sci Rep ISSNコード:2045232220452322 |
掲載区分 | 国外 |
巻・号・頁 | 9(1),pp.13658 |
著者・共著者 | Okuno Keisuke, Naito Yoshiro, Yasumura Seiki, Sawada Hisashi, Asakura Masanori, Masuyama Tohru, Ishihara Masaharu |
発行年月 | 2019/09 |
概要 | Limb ischemia (LI) is a major consequence of peripheral artery disease (PAD) with a high mortality rate. Iron is an essential mineral to maintain physiological function of multiple organs. Intracellular iron transport is regulated by transferrin receptor 1 (TfR1). Although increase in serum ferritin levels has been reported in PAD patients, the mechanism of iron metabolism in LI is still unclear. The aim of this study is to investigate whether TfR1 deletion attenuates LI formation. To generate LI, the left femoral artery of 8-10 week-old C57BL6/J male mice was ligated. Adductor muscles were harvested at 28 days after surgery to investigate iron metabolism. The level of ferritin, intracellular iron storage protein, was higher in ischemic adductor muscles compared to non-ischemic adductor muscles. Level of intracellular iron transport protein, TfR1, was decreased in ischemic adductor muscles. LI was then generated in TfR1 heterozygous deleted mice (TfR1+/- |
DOI | 10.1038/s41598-019-49983-4 |
PMID | 31541184 |