Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Interleukin-1/-33 Signaling Pathways as Therapeutic Targets for Endometriosis. |
Journal | Formal name:Frontiers in immunology Abbreviation:Front Immunol ISSN code:1664322416643224 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 10,pp.2021 |
Papers・Author | Kato Toru, Yasuda Koubun, Matsushita Kazufumi, Ishii Ken J, Hirota Seiichi, Yoshimoto Tomohiro, Shibahara Hiroaki |
Publication date | 2019/08 |
Papers・Description | Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6-10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well-elucidated. Several inflammatory cytokines are reported to participate in the onset of endometriosis. Here, we examined the role of interleukin (IL)-1/IL-33 signaling in the development of endometriosis using a mouse model of endometriosis. Endometriotic lesion volume was significantly reduced inIl33 |
DOI | 10.3389/fimmu.2019.02021 |
PMID | 31507610 |