教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Interleukin-1/-33 Signaling Pathways as Therapeutic Targets for Endometriosis. |
掲載誌名 | 正式名:Frontiers in immunology 略 称:Front Immunol ISSNコード:1664322416643224 |
掲載区分 | 国外 |
巻・号・頁 | 10,pp.2021 |
著者・共著者 | Kato Toru, Yasuda Koubun, Matsushita Kazufumi, Ishii Ken J, Hirota Seiichi, Yoshimoto Tomohiro, Shibahara Hiroaki |
発行年月 | 2019/08 |
概要 | Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6-10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well-elucidated. Several inflammatory cytokines are reported to participate in the onset of endometriosis. Here, we examined the role of interleukin (IL)-1/IL-33 signaling in the development of endometriosis using a mouse model of endometriosis. Endometriotic lesion volume was significantly reduced inIl33 |
DOI | 10.3389/fimmu.2019.02021 |
PMID | 31507610 |