Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Relationship between YKL-40 and pulmonary arterial hypertension in systemic sclerosis. |
Journal | Formal name:Modern rheumatology Abbreviation:Mod Rheumatol ISSN code:1439760914397595 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 29(3),pp.476-483 |
Papers・Author | Furukawa Tetsuya, Matsui Kiyoshi, Kitano Masayasu, Yokoyama Yuichi, Sekiguchi Masahiro, Azuma Naoto, Imai Yasutomo, Hirota Seiichi, Yamanishi Kiyofumi, Sano Hajime. |
Publication date | 2019/05 |
Papers・Description | OBJECTIVES:Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD)and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 blood levels in identifying patients with SSc complicated by PAH, as confirmed by immunohistochemistry (IHC) examination.METHODS:We retrospectively analyzed 78 patients with SSc and performed IHC on 7 normal and 7 SSc skin samples in the Japanese population. Age-adjusted YKL-40 serum levels were analyzed.RESULTS:YKL-40 age percentile was significantly elevated in SSc patients. There was no difference between patients with SSc with and without ILD and PAH. YKL-40 age percentile was greater in patients with PAH complication. YKL-40 immunostaining was negative in normal skin and prominent in the subcutaneous vascular wall of all SSc samples. |
DOI | 10.1080/14397595.2018.1480256 |
PMID | 29788800 |