Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Eye movement activity in normal human fetuses between 24 and 39 weeks of gestation. |
Journal | Formal name:PloS one Abbreviation:PLoS One ISSN code:1932620319326203 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 12(7),pp.e0178722 |
Papers・Author | Okawa Hikohiro, Morokuma Seiichi, Maehara Kana, Arata Akiko, Ohmura Yoshiyuki, Horinouchi Takashi, Konishi Yukuo, Kato Kiyoko |
Publication date | 2017 |
Papers・Description | Rapid eye movement (REM) sleep occurs throughout a relatively large proportion of early development, and normal REM activity appears to be required for healthy brain development. The eye movements (EMs) observed during REM sleep are the most distinctive characteristics of this state. EMs are used as an index of neurological function postnatally, but no specific indices of EM activity exist for fetuses. We aimed to identify and characterize EM activity, particularly EM bursts suggestive of REM periods, in fetuses with a gestational age between 24 and 39 weeks. This cross-sectional study included 84 normal singleton pregnancies. Fetal EMs were monitored using real-time ultrasonography for 60 min and recorded as videos. The videos were manually converted into a time series of EM events, which were then analyzed by piecewise linear regression for various EM characteristics, including EM density, EM burst density, density of EMs in EM bursts, |
DOI | 10.1371/journal.pone.0178722 |
PMID | 28700709 |