Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Activity of swallowing-related neurons in the medulla in the perfused brainstem preparation in rats. |
Journal | Formal name:The Laryngoscope Abbreviation:Laryngoscope ISSN code:153149950023852X |
Domestic / Foregin | Foregin |
Volume, Number, Page | 129(2),pp.E72-E79 |
Papers・Author | Hashimoto Keiko, Sugiyama Yoichiro, Fuse Shinya, Umezaki Toshiro, Oku Yoshitaka, Dutschmann Mathias, Hirano Shigeru |
Publication date | 2019/02 |
Papers・Description | OBJECTIVES/HYPOTHESIS:We aimed to investigate and validate the cellular activity patterns and the potential topographical organization of neurons of the medullary swallowing pattern generator (Sw-CPG). We used the perfused brainstem preparation as an innovative experimental model that allows for stable neuronal recording in the brainstem.STUDY DESIGN:Animal model.METHODS:Experiments were conducted in 14 juvenile Wistar rats. The activities of the phrenic, vagus, and hypoglossal nerves were recorded at baseline, and fictive swallowing was elicited by stimulation of the superior laryngeal nerve. Extracellular action potentials of 72 swallowing-related neurons were recorded in the Sw-CPG of the dorsal medulla oblongata.RESULTS:Neurons could be classified into three types: sensory relay, and neurons that were excited or inhibited during fictive swallowing. Approximately one-third of the neurons likely received monosynaptic input from the laryngeal afferents. |
DOI | 10.1002/lary.27401 |
PMID | 30408193 |