教員業績データベース |
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論文種別 | 総説 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Neural regeneration by regionally induced stem cells within post-stroke brains: Novel therapy perspectives for stroke patients. |
掲載誌名 | 正式名:World journal of stem cells 略 称:World J Stem Cells ISSNコード:1948021019480210 |
掲載区分 | 国外 |
巻・号・頁 | 11(8),pp.452-463 |
著者・共著者 | Nakagomi Takayuki, Takagi Toshinori, Beppu Mikiya, Yoshimura Shinichi, Matsuyama Tomohiro. |
発行年月 | 2019/08 |
概要 | Ischemic stroke is a critical disease which causes serious neurological functional loss such as paresis. Hope for novel therapies is based on the increasing evidence of the presence of stem cell populations in the central nervous system (CNS) and the development of stem-cell-based therapies for stroke patients. Although mesenchymal stem cells (MSCs) represented initially a promising cell source, only a few transplanted MSCs were present near the injured areas of the CNS. Thus, regional stem cells that are present and/or induced in the CNS may be ideal when considering a treatment following ischemic stroke. In thiscontext, we have recently showed that injury/ischemia-induced neural stem/progenitor cells (iNSPCs) and injury/ischemia-induced multipotent stem cells (iSCs) are present within post-stroke human brains and post-stroke mouse brains. This indicates that iNSPCs/iSCs could be developed for clinical applications treating patients with stroke. The present study introduces... |
DOI | 10.4252/wjsc.v11.i8.452 |
PMID | 31523366 |