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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Potential of Adult Endogenous Neural Stem/Progenitor Cells in the Spinal Cord to Contribute to Remyelination in Experimental Autoimmune Encephalomyelitis.
掲載誌名	正式名：Cells 略　 称：Cells ISSNコード：2073440920734409
掲載区分	国外
巻・号・頁	8(9),pp.1025
著者・共著者	Maeda Yuki, Nakagomi Nami, Nakano-Doi Akiko, Ishikawa Hiroto, Tatsumi Yoshiki, Bando Yoshio, Yoshikawa Hiroo, Matsuyama Tomohiro, Gomi Fumi, Nakagomi Takayuki
発行年月	2019/09
概要	Demyelination and remyelination play pivotal roles in the pathological process of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), a well-established animal model of MS. Although increasing evidence shows that various stimuli can promote the activation/induction of endogenous neural stem/progenitor cells (NSPCs) in the central nervous system, the potential contributions of these cells to remyelination following inflammatory injury remain to be fully investigated. In the present study, using an adult mouse model of EAE induced by myelin oligodendrocyte glycoprotein (MOG) peptide, we investigated whether adult NSPCs in the spinal cord can lead to remyelination under inflammatory conditions. Immunohistochemistry showed that cells expressing the NSPC marker Nestin appeared after MOG peptide administration, predominantly at the sites of demyelination where abundant inflammatory cells had accumulated, whereas Nestin+
DOI	10.3390/cells8091025
PMID	31484369