 Faculty Information |
|
| Article types | Original article |
| Language | English |
| Refereed paper | Refereed |
| Title | Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury. |
| Journal | Formal name：International journal of molecular sciences Abbreviation：Int J Mol Sci ISSN code：1422006714220067 |
| Domestic / Foregin | Foregin |
| Volume, Number, Page | 20,pp.7 |
| Papers・Author | Suzuki Chigure, Tanida Isei, Ohmuraya Masaki, Oliva Trejo Juan Alejandro, Kakuta Soichiro, Sunabori Takehiko, Uchiyama Yasuo |
| Publication date | 2019/04 |
| Papers・Description | Cathepsin D is one of the major lysosomal aspartic proteases that is essential for the normal functioning of the autophagy-lysosomal system. In the kidney, cathepsin D is enriched in renal proximal tubular epithelial cells, and its levels increase during acute kidney injury. To investigate how cathepsin D-deficiency impacts renal proximal tubular cells, we employed a conditional knockoutCtsDflox/- |
| DOI | 10.3390/ijms20071711 |
| PMID | 30959855 |