Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury. |
Journal | Formal name:International journal of molecular sciences Abbreviation:Int J Mol Sci ISSN code:1422006714220067 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 20,pp.7 |
Papers・Author | Suzuki Chigure, Tanida Isei, Ohmuraya Masaki, Oliva Trejo Juan Alejandro, Kakuta Soichiro, Sunabori Takehiko, Uchiyama Yasuo |
Publication date | 2019/04 |
Papers・Description | Cathepsin D is one of the major lysosomal aspartic proteases that is essential for the normal functioning of the autophagy-lysosomal system. In the kidney, cathepsin D is enriched in renal proximal tubular epithelial cells, and its levels increase during acute kidney injury. To investigate how cathepsin D-deficiency impacts renal proximal tubular cells, we employed a conditional knockoutCtsDflox/- |
DOI | 10.3390/ijms20071711 |
PMID | 30959855 |