教員業績データベース |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury. |
掲載誌名 | 正式名:International journal of molecular sciences 略 称:Int J Mol Sci ISSNコード:1422006714220067 |
掲載区分 | 国外 |
巻・号・頁 | 20,pp.7 |
著者・共著者 | Suzuki Chigure, Tanida Isei, Ohmuraya Masaki, Oliva Trejo Juan Alejandro, Kakuta Soichiro, Sunabori Takehiko, Uchiyama Yasuo |
発行年月 | 2019/04 |
概要 | Cathepsin D is one of the major lysosomal aspartic proteases that is essential for the normal functioning of the autophagy-lysosomal system. In the kidney, cathepsin D is enriched in renal proximal tubular epithelial cells, and its levels increase during acute kidney injury. To investigate how cathepsin D-deficiency impacts renal proximal tubular cells, we employed a conditional knockoutCtsDflox/- |
DOI | 10.3390/ijms20071711 |
PMID | 30959855 |