教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. |
掲載誌名 | 正式名:iScience 略 称:iScience ISSNコード:2589004225890042 |
掲載区分 | 国外 |
巻・号・頁 | 15,pp.536-551 |
著者・共著者 | Shindo Ryodai, Ohmuraya Masaki, Komazawa-Sakon Sachiko, Miyake Sanae, Deguchi Yutaka, Yamazaki Soh, Nishina Takashi, Yoshimoto Takayuki, Kakuta Soichiro, Koike Masato, Uchiyama Yasuo, Konishi Hiroyuki, Kiyama Hiroshi, Mikami Tetuo, Moriwaki Kenta, Araki Kimi, Nakano Hiroyasu |
発行年月 | 2019/05 |
概要 | A short form of cellular FLICE-inhibitory protein encoded by CFLARs promotes necroptosis. Although necroptosis is involved in various pathological conditions, the detailed mechanisms are not fully understood. Here we generated transgenic mice wherein CFLARs was integrated onto the X chromosome. All male CFLARs Tg mice died perinatally due to severe ileitis. Although necroptosis was observed in various tissues of CFLARs Tg mice, large numbers of intestinal epithelial cells (IECs) died by apoptosis. Deletion of Ripk3 or Mlkl, essential genes of necroptosis, prevented both necroptosis and apoptosis, and rescued lethality of CFLARs Tg mice. Type 3 innate lymphoid cells (ILC3s) were activated and recruited to the small intestine along with upregulation of interleukin-22 (Il22) in CFLARs Tg mice. Deletion of ILC3s or Il22 rescued lethality of CFLARs Tg mice by preventing apoptosis, but not necroptosis of IECs. |
DOI | 10.1016/j.isci.2019.05.011 |
PMID | 31132747 |