Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Adipose-derived stem cell therapy inhibits the deterioration of cerebral infarction by altering macrophage kinetics. |
Journal | Formal name:Brain research Abbreviation:Brain Res ISSN code:1872624000068993 |
Domestic / Foregin | Foregin |
Volume, Number, Page | 1712,pp.139-150 |
Papers・Author | Tatebayashi Kotaro, Takagi Toshinori, Fujita Mitsugu, Doe Nobutaka, Nakagomi Takayuki, Matsuyama Tomohiro, Yoshimura Shinichi |
Publication date | 2019/06 |
Papers・Description | INTRODUCTION:We previously established a method to isolate and culture human adipose-derived stem cells (hADSCs) using fetal bovine serum and showed the therapeutic impact on cerebral infarction. Recently, we modified the culture method with the use of serum-free media for future clinical applications. This study aims to evaluate whether intravenous administration of hADSCs induced by the serum-free culture method would improve neurobehavioral deficits in mice with cerebral infarction.RESULTS:Induced hADSCs possessed the characteristics of mesenchymal stem cells and withstood a freeze-thaw process. hADSC administration improved neurobehavioral deficits in MCAO-treated mice and suppressed brain atrophy at the chronic phase. Although hADSC administration did not affect serum cytokine profiles, it decreased the number of CD11b+DISCUSSION:Our data indicate that the |
DOI | 10.1016/j.brainres.2019.01.037 |
PMID | 30721668 |