教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Adipose-derived stem cell therapy inhibits the deterioration of cerebral infarction by altering macrophage kinetics. |
掲載誌名 | 正式名:Brain research 略 称:Brain Res ISSNコード:1872624000068993 |
掲載区分 | 国外 |
巻・号・頁 | 1712,pp.139-150 |
著者・共著者 | Tatebayashi Kotaro, Takagi Toshinori, Fujita Mitsugu, Doe Nobutaka, Nakagomi Takayuki, Matsuyama Tomohiro, Yoshimura Shinichi |
発行年月 | 2019/06 |
概要 | INTRODUCTION:We previously established a method to isolate and culture human adipose-derived stem cells (hADSCs) using fetal bovine serum and showed the therapeutic impact on cerebral infarction. Recently, we modified the culture method with the use of serum-free media for future clinical applications. This study aims to evaluate whether intravenous administration of hADSCs induced by the serum-free culture method would improve neurobehavioral deficits in mice with cerebral infarction.RESULTS:Induced hADSCs possessed the characteristics of mesenchymal stem cells and withstood a freeze-thaw process. hADSC administration improved neurobehavioral deficits in MCAO-treated mice and suppressed brain atrophy at the chronic phase. Although hADSC administration did not affect serum cytokine profiles, it decreased the number of CD11b+DISCUSSION:Our data indicate that the |
DOI | 10.1016/j.brainres.2019.01.037 |
PMID | 30721668 |