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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction.
掲載誌名	正式名：PloS one 略　 称：PLoS One ISSNコード：1932-6203(Electronic)1932-6203(Linking)
掲載区分	国外
巻・号・頁	13(12),pp.e0208396
著者・共著者	Yamamoto Tsunehisa, Endo Jin, Kataoka Masaharu, Matsuhashi Tomohiro, Katsumata Yoshinori, Shirakawa Kohsuke, Yoshida Naohiro, Isobe Sarasa, Moriyama Hidenori, Goto Shinichi, Yamashita Kaoru, Nakanishi Hiroki, Shimanaka Yuta, Kono Nozomu, Shinmura Ken, Arai Hiroyuki, Fukuda Keiichi, Sano Motoaki
発行年月	2018/12
概要	Increase in saturated fatty acid (SFA) content in membrane phospholipids dramatically affects membrane properties and cellular functioning. We sought to determine whether exogenous SFA from the diet directly affects the degree of membrane phospholipid unsaturation in adult hearts and if these changes correlate with contractile dysfunction. Although both SFA-rich high fat diets (HFDs) and monounsaturated FA (MUFA)-rich HFDs cause the same degree of activation of myocardial FA uptake, triglyceride turnover, and mitochondrial FA oxidation and accumulation of toxic lipid intermediates, the former induced more severe diastolic dysfunction than the latter, which was accompanied with a decrease in membrane phospholipid unsaturation,induction of unfolded protein response (UPR), and a decrease in the expression of Sirt1 and stearoyl-CoA desaturase-1 (SCD1), catalyzing the conversion of SFA to MUFA. When the SFA supply in the heart overwhelms the cellular capacity to use it for energy, excess exogenous SFA channels to membrane phospholipids, leading to UPR induction, and development of diastolic dysfunction.
DOI	10.1371/journal.pone.0208396
PMID	30533011