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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Proposed model for the prediction of intrahepatic covalently closed circular DNA level in patients with chronic hepatitis B.
掲載誌名	正式名：Hepatology research : the official journal of the Japan Society of Hepatology 略　 称：Hepatol Res ISSNコード：1386-6346(Print)1386-6346(Linking)
掲載区分	国外
出版社	WILEY
巻・号・頁	49(3),pp.271-283
著者・共著者	Hasegawa Kunihiro, Nishikawa Hiroki, Enomoto Hirayuki, Iwata Yoshinori, Sakai Yoshiyuki, Ikeda Naoto, Takashima Tomoyuki, Aizawa Nobuhiro, Takata Ryo, Yoh Kazunori, Ishii Noriko, Yuri Yukihisa, Nishimura Takashi, Iijima Hiroko, Hatano Etsuro, Fujimoto Jiro, Nishiguchi Shuhei.
発行年月	2019/03
概要	AIM:We sought to create a prediction model for intrahepatic covalently closed circular DNA (IH-cccDNA) level in chronic hepatitis B (CHB) patients and to validate the model's predictive accuracy.METHODS:Patients who did not receive previous nucleoside analogue (NA) therapy were assigned to the training cohort (n = 57), and those who received previous NA therapy were assigned to the validation cohort (n = 69). Factors linked to IH-cccDNA levels in the training cohort were analyzed and a formula to predict IH-cccDNA levels was constructed. Next, the reproducibility of that formula was assessed.RESULTS:In the multivariate analysis for the prediction of IH-cccDNA level in the training cohort, fasting blood sugar (FBS) (P = 0.0227), hepatitis B e antigen (HBeAg) (P = 0.0067) and log10CONCLUSION:Our proposed model for the prediction of IH-cccDNA level could be helpful in CHB patients.
DOI	10.1111/hepr.13280.
PMID	30358027