教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Immunohistochemical characterization of cancer-associated fibroblasts at the primary sites and in the metastatic lymph nodes of human intrahepatic cholangiocarcinoma |
掲載誌名 | 正式名:Human pathology 略 称:Hum Pathol ISSNコード:1532-8392(Electronic)0046-8177(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 83,pp.77-89 |
著者・共著者 | Itou Rei Atono, Uyama Naoki, Hirota Seiichi, Kawada Norifumi, Wu Songtao, Miyashita Seikan, Nakamura Ikuo, Suzumura Kazuhiro, Sueoka Hideaki, Okada Tosihiro, Hatano Etsuro, Tsutsui Hiroko, Fujimoto Jiro |
発行年月 | 2018/08 |
概要 | Cancer-associated fibroblasts (CAFs) are an important constituent of the cancer stroma. In intrahepatic cholangiocarcinoma (ICC), the features of CAFs at the primary site and in the metastatic lymph nodes (Met-LNs) and their origin have been unclear. In the present study, we characterized CAFs at the primary site (n=42) and in the Met-LNs (n=10) of human ICC by immunohistochemistry using potential molecular markers of CAFs, portal fibroblasts (PFs), hepatic stellate cells (HSCs) and bone marrow-derived fibrocytes (BMDFs). At the primary site, the stroma was strongly positive for α-SMA (marker for CAFs), PDGFR-β (common marker for HSCs and PFs), fibulin-2 and Thy-1 (PF marker), while immunoreactivity for fascin (HSC marker) was scarce. A majority of the α-SMA-positive cells were found to express PDGFR-β, Thy-1 and fibulin-2 by double immunostaining. A small population of BMDF marker-positive (α-SMA+ |
DOI | 10.1016/j.humpath.2018.08.016 |
PMID | 30172911 |