Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours. |
Journal | Formal name:Scientific reports Abbreviation:Sci Rep ISSN code:2045-2322(Electronic)2045-2322(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 7(1),pp.4739 |
Papers・Author | Koga Keisuke, Kanehisa Kensho, Kohro Yuta, Shiratori-Hayashi Miho, Tozaki-Saitoh Hidetoshi, Inoue Kazuhide, Furue Hidemasa, Tsuda Makoto |
Publication date | 2017/07 |
Papers・Description | Inhibitory interneurons in the spinal dorsal horn (SDH) are crucial for processing somatosensory information originating in the periphery. However, the effects of the acute and selective inactivation of GABAergic SDH interneurons on pain processing are not fully understood. In this study, we used designer receptors exclusively activated by designer drugs (DREADD) technology and vesicular GABA transporter-Cre (Vgat-Cre) mice to selectively express a modified human muscarinic Gi protein-coupled receptor (hM4Di) in Vgat-Cre+ |
DOI | 10.1038/s41598-017-04972-3 |
PMID | 28680103 |