教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours. |
掲載誌名 | 正式名:Scientific reports 略 称:Sci Rep ISSNコード:2045-2322(Electronic)2045-2322(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 7(1),pp.4739 |
著者・共著者 | Koga Keisuke, Kanehisa Kensho, Kohro Yuta, Shiratori-Hayashi Miho, Tozaki-Saitoh Hidetoshi, Inoue Kazuhide, Furue Hidemasa, Tsuda Makoto |
発行年月 | 2017/07 |
概要 | Inhibitory interneurons in the spinal dorsal horn (SDH) are crucial for processing somatosensory information originating in the periphery. However, the effects of the acute and selective inactivation of GABAergic SDH interneurons on pain processing are not fully understood. In this study, we used designer receptors exclusively activated by designer drugs (DREADD) technology and vesicular GABA transporter-Cre (Vgat-Cre) mice to selectively express a modified human muscarinic Gi protein-coupled receptor (hM4Di) in Vgat-Cre+ |
DOI | 10.1038/s41598-017-04972-3 |
PMID | 28680103 |