Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats. |
Journal | Formal name:American journal of physiology. Gastrointestinal and liver physiology Abbreviation:Am J Physiol Gastrointest Liver Physiol ISSN code:1522-1547(Electronic)0193-1857(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 314(3),pp.G341-G348 |
Papers・Author | Nakamori Hiroyuki, Naitou Kiyotada, Horii Yuuki, Shimaoka Hiroki, Horii Kazuhiro, Sakai Hiroki, Yamada Akihiro, Furue Hidemasa, Shiina Takahiko, Shimizu Yasutake |
Publication date | 2018/03 |
Papers・Description | Colorectal motility is regulated by two defecation centers located in the brain and spinal cord. In previous studies, we have shown that administration of serotonin (5-HT) in the lumbosacral spinal cord causes enhancement of colorectal motility. Because spinal 5-HT is derived from neurons of the medullary raphe nuclei, including the raphe magnus, raphe obscurus, and raphe pallidus, we examined whether stimulation of the medullary raphe nuclei enhances colorectal motility via the lumbosacral defecation center. Colorectal pressure was recorded with a balloon in vivo in anesthetized rats. Electrical stimulation of the medullary raphe nuclei failed to enhance colorectal motility. Because GABAergic neurons can be simultaneously activated by the raphe stimulation and released GABA masks accelerating actions of the raphe nuclei on the lumbosacral defecation center, a GABAA |
DOI | 10.1152/ajpgi.00317.2017 |
PMID | 29167116 |