教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats. |
掲載誌名 | 正式名:American journal of physiology. Gastrointestinal and liver physiology 略 称:Am J Physiol Gastrointest Liver Physiol ISSNコード:1522-1547(Electronic)0193-1857(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 314(3),pp.G341-G348 |
著者・共著者 | Nakamori Hiroyuki, Naitou Kiyotada, Horii Yuuki, Shimaoka Hiroki, Horii Kazuhiro, Sakai Hiroki, Yamada Akihiro, Furue Hidemasa, Shiina Takahiko, Shimizu Yasutake |
発行年月 | 2018/03 |
概要 | Colorectal motility is regulated by two defecation centers located in the brain and spinal cord. In previous studies, we have shown that administration of serotonin (5-HT) in the lumbosacral spinal cord causes enhancement of colorectal motility. Because spinal 5-HT is derived from neurons of the medullary raphe nuclei, including the raphe magnus, raphe obscurus, and raphe pallidus, we examined whether stimulation of the medullary raphe nuclei enhances colorectal motility via the lumbosacral defecation center. Colorectal pressure was recorded with a balloon in vivo in anesthetized rats. Electrical stimulation of the medullary raphe nuclei failed to enhance colorectal motility. Because GABAergic neurons can be simultaneously activated by the raphe stimulation and released GABA masks accelerating actions of the raphe nuclei on the lumbosacral defecation center, a GABAA |
DOI | 10.1152/ajpgi.00317.2017 |
PMID | 29167116 |