教員業績データベース |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders. |
掲載誌名 | 正式名:Journal of neurogastroenterology and motility 略 称:J Neurogastroenterol Motil ISSNコード:2093-0879(Print)2093-0879(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 24(3),pp.367-386 |
著者・共著者 | Fukui Hirokazu, Xu Xin, Miwa Hiroto |
発行年月 | 2018/07 |
概要 | Gut microbiota exert a pivotal influence on various functions including gastrointestinal (GI) motility, metabolism, nutrition, immunity, and the neuroendocrine system in the host. These effects are mediated by not only short-chain fatty acids produced by microbiota but also gut hormones and inflammatory signaling by enteroendocrine and immune cells under the influence of the microbiota. GI motility is orchestrated by the enteric nervous system and hormonal networks, and disturbance of GI motility plays an important role in the pathophysiology of functional gastrointestinal disorders (FGIDs). In this context, microbiota-associated mediators are considered to act on specific receptors, thus affecting the enteric nervous system and, subsequently, GI motility. Thus, the pathophysiology of FGIDs is based on alterations of the gut microbiota/gut hormone axis, which have crucial effects on GI motility. |
DOI | 10.5056/jnm18071 |
PMID | 29969855 |