教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration. |
掲載誌名 | 正式名:eLife 略 称:Elife ISSNコード:2050-084X(Electronic)2050-084X(Linking) |
掲載区分 | 国外 |
巻・号・頁 | pp.7 |
著者・共著者 | Miura Yasushi, Matsui Satoshi, Miyata Naoko, Harada Kenichi, Kikkawa Yamato, Ohmuraya Masaki, Araki Kimi, Tsurusaki Shinya, Okochi Hitoshi, Goda Nobuhito, Miyajima Atsushi, Tanaka Minoru |
発行年月 | 2018/07 |
概要 | Under chronic or severe liver injury, liver progenitor cells (LPCs) of biliary origin are known to expand and contribute to the regeneration of hepatocytes and cholangiocytes. This regeneration process is called ductular reaction (DR), which is accompanied by dynamic remodeling of biliary tissue. Although the DR shows apparently distinct mode of biliary extension depending on the type of liver injury, the key regulatory mechanism remains poorly understood. Here, we show that Lutheran (Lu)/Basal cell adhesion molecule (BCAM) regulates the morphogenesis of DR depending on liver disease models. Lu+ |
DOI | 10.7554/eLife.36572 |
PMID | 30059007 |