Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | PDCD1 and CTLA4 polymorphisms affect the susceptibility to, and clinical features of, chronic immune thrombocytopenia. |
Journal | Formal name:British journal of haematology Abbreviation:Br J Haematol ISSN code:1365-2141(Electronic)0007-1048(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 180(5),pp.705-714 |
Papers・Author | Kasamatsu Tetsuhiro, Ino Rumi, Takahashi Noriyuki, Gotoh Nanami, Minato Yusuke, Takizawa Makiko, Yokohama Akihiko, Handa Hiroshi, Saitoh Takayuki, Tsukamoto Norifumi, Murakami Hirokazu |
Publication date | 2018/03 |
Papers・Description | Programmed death-1 (PD-1, PDCD1) and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4, CTLA4) play central roles in immune checkpoint pathways. Single nucleotide polymorphisms (SNPs) of PDCD1 and CTLA4 have been reported to be associated with susceptibility to some autoimmune diseases. However, the potential association between SNPs in these immune checkpoint genes and risk of chronic immune thrombocytopenia (cITP) remain controversial and obscure. The aims of this study were to clarify the influence of PDCD1 and CTLA4 SNPs on the risk of developing cITP and its clinical features. We obtained genomic DNA from 119 patients with cITP and 223 healthy controls; their genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Patients with cITP had a significantly higher frequency of the PDCD1 +7209 TT genotype compared with healthy controls. The CTLA4 -1577 GG genotype and CT60 GG genotype showed higher frequencies of platelet count<5 × 109 |
DOI | 10.1111/bjh.15085 |
PMID | 29359792 |