教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys. |
掲載誌名 | 正式名:Proceedings of the National Academy of Sciences of the United States of America 略 称:Proc Natl Acad Sci U S A ISSNコード:1091-6490(Electronic)0027-8424(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 115(14),pp.E3211-E3220 |
著者・共著者 | Holland Stephen J, Berghuis Lesley M, King Justin J, Iyer Lakshminarayan M, Sikora Katarzyna, Fifield Heather, Peter Sarah, Quinlan Emma M, Sugahara Fumiaki, Shingate Prashant, Trancoso Inês, Iwanami Norimasa, Temereva Elena, Strohmeier Christine, Kuratani Shigeru, Venkatesh Byrappa, Evanno Guillaume, Aravind L, Schorpp Michael, Larijani Mani, Boehm Thomas |
発行年月 | 2018/04 |
概要 | Cytidine deaminases of the AID/APOBEC family catalyze C-to-U nucleotide transitions in mRNA or DNA. Members of the APOBEC3 branch are involved in antiviral defense, whereas AID contributes to diversification of antibody repertoires in jawed vertebrates via somatic hypermutation, gene conversion, and class switch recombination. In the extant jawless vertebrate, the lamprey, two members of the AID/APOBEC family are implicated in the generation of somatic diversity of the variable lymphocyte receptors (VLRs). Expression studies linkedCDA1 |
DOI | 10.1073/pnas.1720871115 |
PMID | 29555777 |