教員業績データベース |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors - Hyogo Sleep Cardio-Autonomic Atherosclerosis study. |
掲載誌名 | 正式名:PloS one 略 称:PLoS One ISSNコード:1932-6203(Electronic)1932-6203(Linking) |
巻・号・頁 | 12(6),pp.e0178686 |
著者・共著者 | Kurajoh Masafumi, Kadoya Manabu, Morimoto Akiko, Miyoshi Akio, Kanzaki Akinori, Kakutani-Hatayama Miki, Hamamoto Kae, Shoji Takuhito, Moriwaki Yuji, Yamamoto Tetsuya, Inaba Masaaki, Namba Mitsuyoshi, Koyama Hidenori |
発行年月 | 2017 |
概要 | BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been shown to have protective effects against cardiovascular diseases and death through neural and non-neural pathways via tropomyosin-related kinase B signaling. However, it is not known whether plasma BDNF concentration is a predictor of chronic kidney disease (CKD).DESIGN:This study was conducted as a prospective cohort study as part of the Hyogo Sleep Cardio-Autonomic Atherosclerosis.METHODS:We measured plasma BDNF concentration in 324 patients without CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, and with cardiovascular risk factors. As potential confounders, sleep condition, nocturnal hypertension, and autonomic function were quantitatively examined. The patients were followed for a median 37 months (range 2-59 months) and occurrence of CKD was noted.RESULTS:Plasma BDNF concentration was significantly and independently associated with CKD development, which occurred in 38 patients (11.7%). Kaplan-Meier analysis revealed that patients with reduced plasma BDNF concentration exhibited a significantly (p = 0.029) greater number of CKD events as compared to those with a higher concentration. Moreover, comparisons of key subgroups showed that the risk of CKD in association with low plasma BDNF concentration was more prominent in patients with a greater reduction of nocturnal systolic blood pressure, better movement index, higher standard deviations of the NN(RR) interval or average NN(RR) interval for each 5-minute period, and without past cardiovascular disease events, smoking habit, or albuminuria.CONCLUSIONS:Plasma BDNF concentration is an independent predictor for development of CKD in patients with cardiovascular risk factors. |
DOI | 10.1371/journal.pone.0178686 |
PMID | 28575038 |