1.  

Article types	Original article
Language	English
Refereed paper	Refereed
Title	Circadian rhythms of micturition during jet lag
Journal	Formal name：Biomedical research (Tokyo, Japan) Abbreviation：Biomed Res ISSN code：1880-313X(Electronic)0388-6107(Linking)
Domestic / Foregin	Domestic
Volume, Number, Page	39(2),pp.57-63
Papers・Author	Ito Kakeru, Yasuda Miho, Maeda Yuki, Fustin Jean-Michel, Yamaguchi Yoshiaki, Kono Yuka, Negoro Hiromitsu, Kanematsu Akihiro, Ogawa Osamu, Doi Masao, Okamura Hitoshi
Publication date	2018/04
Papers・Description	Micturition behavior follows regular day/night fluctuations, and unwanted increase in micturition could occur during night in jet lag condition. To clarify the effect of jet lag on micturition behavior, we simultaneously detected circadian micturition patterns and locomotor activity rhythms of mice under experimental jet lag conditions, by applying the improved automated Voided Stain on Paper (aVSOP) method. When wild-type (WT) mice were phase-advanced for 8 hours, day-night variation of micturition was disrupted suddenly, and this irregular daily micturition continued until 8 days, although their activity rhythms entrained gradually day by day until 8 days. We also examined how jet lag induced changes of micturition in Per-null mice lacking Per1, Per2 and Per3 genes, whose endogenous clock is completely disrupted.
DOI	10.2220/biomedres.39.57
The document number	2019042991
PMID	29669984