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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Circadian rhythms of micturition during jet lag
掲載誌名	正式名：Biomedical research (Tokyo, Japan) 略　 称：Biomed Res ISSNコード：1880-313X(Electronic)0388-6107(Linking)
掲載区分	国内
巻・号・頁	39(2),pp.57-63
著者・共著者	Ito Kakeru, Yasuda Miho, Maeda Yuki, Fustin Jean-Michel, Yamaguchi Yoshiaki, Kono Yuka, Negoro Hiromitsu, Kanematsu Akihiro, Ogawa Osamu, Doi Masao, Okamura Hitoshi
発行年月	2018/04
概要	Micturition behavior follows regular day/night fluctuations, and unwanted increase in micturition could occur during night in jet lag condition. To clarify the effect of jet lag on micturition behavior, we simultaneously detected circadian micturition patterns and locomotor activity rhythms of mice under experimental jet lag conditions, by applying the improved automated Voided Stain on Paper (aVSOP) method. When wild-type (WT) mice were phase-advanced for 8 hours, day-night variation of micturition was disrupted suddenly, and this irregular daily micturition continued until 8 days, although their activity rhythms entrained gradually day by day until 8 days. We also examined how jet lag induced changes of micturition in Per-null mice lacking Per1, Per2 and Per3 genes, whose endogenous clock is completely disrupted.
DOI	10.2220/biomedres.39.57
文献番号	2019042991
PMID	29669984