教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | A lower eicosapentaenoic acid/arachidonic acid ratio is associated with in-hospital fatal arrhythmic events in patients with acute myocardial infarction: a J-MINUET substudy. |
掲載誌名 | 正式名:Heart and vessels 略 称:Heart Vessels ISSNコード:1615-2573(Electronic)0910-8327(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 33(5),pp.481-8 |
著者・共著者 | Hashimoto Takuya, Ako Junya, Nakao Koichi, Ozaki Yukio, Kimura Kazuo, Noguchi Teruo, Yasuda Satoshi, Suwa Satoru, Fujimoto Kazuteru, Nakama Yasuharu, Morita Takashi, Shimizu Wataru, Saito Yoshihiko, Hirohata Atsushi, Morita Yasuhiro, Inoue Teruo, Okamura Atsunori, Uematsu Masaaki, Hirata Kazuhito, Tanabe Kengo, Shibata Yoshisato, Owa Mafumi, Tsujita Kenichi, Funayama Hiroshi, Kokubu Nobuaki, Kozuma Ken, Uemura Shirou, Toubaru Tetsuya, Saku Keijirou, Ohshima Shigeru, Nakai Michikazu, Nishimura Kunihiro, Miyamoto Yoshihiro, Ogawa Hisao, Ishihara Masaharu |
発行年月 | 2018/05 |
概要 | The ratio of serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) is significantly associated with long-term clinical outcomes in patients with acute myocardial infarction (AMI). However, it has not been conclusively demonstrated that higher serum EPA/AA ratio fares better clinical outcomes in the early phase of AMI. The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective multicenter registry conducted in 28 Japanese medical institutions between July 2012 and March 2014. We enrolled 3,283 consecutive AMI patients who were admitted to participatinginstitutions within 48 h of symptom onset. A serum EPA/AA ratio was available for 629 of these patients. The endpoints were in-hospital mortality and major adverse cardiac events (MACE), defined as a composite of all cause death, cardiac failure, ventricular tachycardia (VT) and/or ventricular fibrillation (VF) and bleeding during hospitalization. Although similar rates of in-hospital mortality, cardiac failure, bleeding, and MACE were found in the lower serum EPA/AA group and higher serum EPA/AA group, the incidence of VT/VF during hospitalization was significantly higher in the low ratio group (p = 0.008). Receiver operating characteristic curve analysis showed that an EPA/AA ratio< 0.35 could predict the incidence of VT/VF with 100% sensitivity and 64.0% specificity. A lower serum EPA/AA ratio was associated with a higher frequency of fatal arrhythmic events in the early phase of AMI. |
DOI | 10.1007/s00380-017-1084-2 |
PMID | 29147787 |